3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)benzenemethanol
[CAS# 1632047-58-5]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives
• Name: 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)benzenemethanol
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.30
• CAS Registry Number: 1632047-58-5
• SMILES: C1CC2(CC=C1C3=CC=CC(=C3)CO)OCCO2

Properties

• Density: 1.2±0.1 g/cm³ Calc.^*
• Boiling point: 422.9±45.0 ºC 760 mmHg (Calc.)^*
• Flash point: 210.1±12.5 ºC (Calc.)^*
• Index of refraction: 1.595 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H315-H319-H335
• Precautionary Statements: P261-P305-P351-P338

Discovory and Applicatios

(3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)phenyl)methanol is a relatively recent and specialized compound, and the publicly available data focus mostly on structure, physicochemical properties, and potential as an intermediate rather than a well-documented historical “discovery” story. According to PubChem, its molecular formula is C₁₅H₁₈O₃ and its structure links a benzyl alcohol moiety to a spiro acetal ring (a 1,4-dioxaspiro[4.5]dec-7-en) through a phenyl linker.

Because the discovery timeline or original synthesis publication is not well documented in publicly accessible literature (e.g., common journals or chemical reviews), the “discovery” portion is limited to what can be deduced: the compound likely emerged from modern synthetic organic chemistry efforts to explore spiroacetal-phenyl hybrid molecules, possibly in medicinal chemistry or materials studies. Its structure suggests it could act as a building block or scaffold for further derivatization, especially because benzyl alcohol moieties can be converted to various functional groups (e.g. aldehydes, ethers, esters), and spiroacetal rings have interest in medicinal chemistry (rigid, three-dimensional backbones, conformational constraints, oxygen heterocycles).

As of now, there is no well-documented literature source showing biological activity or industrial application specifically of (3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)phenyl)methanol. The PubChem entry is largely structural. It may serve as an intermediate in synthetic routes or a structural motif in compound libraries used in drug discovery screens. Researchers synthesizing novel small molecules might use it to introduce the spiroacetal ring with an aromatic anchor, allowing further substitution to probe structure–activity relationships.

In practical application, such compounds are often used in medicinal chemistry, agrochemical research, or as components in materials science (for example, as rigid linkers, modifiable handles, or as parts of fluorescent or sensing molecules). The benzyl alcohol function provides a convenient functional handle. The spiroacetal part could confer stereochemical rigidity, influence solubility and permeability, and affect metabolic stability.

References

2021. Quality evaluation method of (3S)-3-(4-(3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)benzyloxy)phenyl)hex-4-ynoic acid. Patent KR-102270026-B1.
Priority Date: 2020-01-31, Grant Date: 2021-06-28

2021. Method for evaluating quality of (3S)-3-(4-(3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)benzyloxy)phenyl)hex-4-ynoic acid. Patent WO-2021154019-A1.
Priority Date: 2020-01-31

2023. Method for evaluating quality of (3S)-3-(4-(3-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)benzyloxy)phenyl)hex-4-ynoic acid. Patent AU-2021214518-B2.
Priority Date: 2020-01-31, Grant Date: 2023-11-16