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Isosorbide dimethyl ether
[CAS 5306-85-4]

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Identification
ClassificationChemical reagent >> Organic reagent >> Ether
NameIsosorbide dimethyl ether
SynonymsDMI; 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
Molecular StructureIsosorbide dimethyl ether molecular structure (CAS 5306-85-4)
Molecular FormulaC8H14O4
Molecular Weight174.19
CAS Registry Number5306-85-4
EC Number226-159-8
SMILESCO[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC
Properties
Density1.2±0.1 g/cm3 Calc.*, 1.165 g/mL (Expl.)
Melting point-70 °C (Expl.)
Boiling point236.4±40.0 °C 760 mmHg (Calc.)*, 393.1 - 396.6 °C (Expl.)
Flash point108.3 °C (Calc.)*, 108 °C (Expl.)
Index of refraction1.466 (Calc.)*, 1.463 (Expl.)
*Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbolssymbol   GHS07 Warning  Details
Risk StatementsH302-H315-H319-H335  Details
Safety StatementsP261-P305+P351+P338  Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Eye irritationEye Irrit.2H319
SDSAvailable
up chemBlink Chemical Story
Isosorbide dimethyl ether matters because dimethyl isosorbide converts a rigid carbohydrate-derived bicyclic framework into a useful polar specialty solvent and carrier. This connection between molecular structure and observable behavior is more informative than a simple list of uses. CAS 5306-85-4 identifies the substance in this chemBlink record, while its practical significance comes from the way its functional groups, composition, or material structure control reactivity and physical properties.

The broader lesson is that chemical identity alone does not determine performance. Conditions such as pH, temperature, formulation, concentration, molecular distribution, or biological environment can decide whether the same underlying chemistry is useful, inactive, or hazardous. For chemists, Isosorbide dimethyl ether is therefore a useful case study in connecting molecular-scale behavior with a real laboratory, industrial, biological, or materials-science outcome.

References: PubChem: Dimethyl Isosorbide; Rose & Palkovits, ChemSusChem 2012

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