Skinasensyl
[CAS# 928007-64-1]

Identification

• Classification: Biochemical >> Peptide
• Name: Skinasensyl
• Synonyms: N-Acetyl-L-tyrosyl-L-prolyl-L-phenylalanyl-L-phenylalaninamide; Acetyl tetrapeptide 15
• Protein Sequence: YPFF
• Molecular Formula: C₃₄H₃₉N₅O₆
• Molecular Weight: 613.70
• CAS Registry Number: 928007-64-1
• EC Number: 895-468-3
• SMILES: CC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N

Properties

• Solubility: Practically insoluble (0.018 g/L) (25 ºC), Calc.^*
• Density: 1.285±0.06 g/cm³ (20 ºC 760 Torr), Calc.^*
• Boiling point: 1055.3±65.0 ºC 760 mmHg (Calc.)^*
• Flash point: 592.0±34.3 ºC (Calc.)^*
• Index of refraction: 1.617 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Discovory and Applicatios

Skinasensyl is a commercial active ingredient used primarily in cosmetic and dermatological formulations for its anti-irritant and soothing properties. Chemically, it is a stabilized dipeptide derivative designed to mitigate skin sensitivity by modulating inflammatory and cellular stress responses in epidermal tissues. The compound is part of a class of small synthetic peptides that act at the molecular level to improve skin tolerance and reduce reactivity to environmental or chemical stimuli.

The discovery of Skinasensyl is linked to research on bioactive peptides for cosmetic applications. Scientists recognized that short peptide sequences could influence cellular signaling pathways involved in inflammation, barrier function, and stress response. By modifying naturally occurring amino acids and creating small, stable peptides, researchers developed compounds capable of interacting with skin cells to decrease the release of pro-inflammatory mediators. These efforts led to the identification and optimization of Skinasensyl as a functional ingredient suitable for topical formulations.

Structurally, Skinasensyl is a low-molecular-weight peptide derivative, often presented as a dipeptide or small oligopeptide with chemical modifications that enhance stability and skin penetration. Such modifications typically include acetylation or protection of reactive groups, ensuring the peptide retains activity in cosmetic formulations while resisting degradation from enzymes or environmental factors. The molecular design allows the peptide to interact with keratinocytes and fibroblasts, helping to regulate stress-activated signaling pathways that lead to redness, irritation, and discomfort.

In terms of applications, Skinasensyl is widely incorporated into skin care products aimed at sensitive skin types. These include creams, lotions, and serums formulated to reduce the incidence of irritation from surfactants, environmental aggressors, or cosmetic actives. Clinical evaluations and in vitro studies have demonstrated that Skinasensyl can decrease the expression of inflammatory markers in skin cells, enhance barrier function, and improve overall skin comfort. Its activity is particularly relevant in products marketed for individuals with reactive or delicate skin.

Beyond its soothing properties, Skinasensyl is valued for its compatibility with other cosmetic ingredients. Its stability under formulation conditions allows it to be incorporated alongside common actives such as moisturizers, antioxidants, and UV filters. This versatility makes it an attractive ingredient in multi-functional products that aim to protect and improve the skin barrier while minimizing potential irritation.

From a regulatory and safety perspective, Skinasensyl has been tested in cosmetic safety studies, including patch tests and controlled human trials, to confirm its low potential for sensitization and irritation. These assessments support its use in consumer products intended for daily application. Its efficacy and tolerability have contributed to its widespread adoption in sensitive skin formulations, making it a notable example of peptide-based cosmetic actives.

Overall, Skinasensyl exemplifies the application of peptide chemistry in dermatological and cosmetic science. Its development illustrates how short, chemically modified peptides can be engineered to influence cellular processes and improve skin health. By combining stability, biological activity, and safety, Skinasensyl has become a key ingredient in formulations designed to soothe, protect, and enhance the tolerance of sensitive skin.

References

2025. Preparation method of acyl tetrapeptides. CN Patent.
URL: CN-120136961-A

2025. Active peptide composition and application thereof in cosmetics. CN Patent.
URL: CN-119174719-B