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Salicylhydroxamic acid
[CAS 89-73-6]

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Identification
ClassificationChemical reagent >> Organic reagent >> Aromatic acid
NameSalicylhydroxamic acid
Synonyms2-Hydroxybenzohydroxamic acid; N,2-Dihydroxybenzamide
Molecular StructureSalicylhydroxamic acid molecular structure (CAS 89-73-6)
Molecular FormulaC7H7NO3
Molecular Weight153.14
CAS Registry Number89-73-6
EC Number201-934-3
SMILESC1=CC=C(C(=C1)C(=O)NO)O
Properties
Density1.4±0.1 g/cm3 Calc.*
Melting point177 °C (Decomposes) (Expl.)
Index of refraction1.626 (Calc.)*
*Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbolssymbol symbol   GHS07;GHS08 Warning  Details
Risk StatementsH312+H332-H312-H315-H319-H332-H335-H351  Details
Safety StatementsP203-P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P317-P318-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501  Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Skin irritationSkin Irrit.2H315
Eye irritationEye Irrit.2H319
Specific target organ toxicity - single exposureSTOT SE3H335
Acute toxicityAcute Tox.4H312
Acute toxicityAcute Tox.4H332
CarcinogenicityCarc.2H351
Germ cell mutagenicityMuta.2H341
SDSAvailable
up chemBlink Chemical Story
Salicylhydroxamic acid matters because the neighboring phenol and hydroxamate groups give salicylhydroxamic acid rich metal-chelation and biochemical behavior, including its use as SHAM in studies of alternative oxidase. This connection between molecular structure and observable behavior is more informative than a simple list of uses. CAS 89-73-6 identifies the substance in this chemBlink record, while its practical significance comes from the way its functional groups, composition, or material structure control reactivity and physical properties.

The broader lesson is that chemical identity alone does not determine performance. Conditions such as pH, temperature, formulation, concentration, molecular distribution, or biological environment can decide whether the same underlying chemistry is useful, inactive, or hazardous. For chemists, Salicylhydroxamic acid is therefore a useful case study in connecting molecular-scale behavior with a real laboratory, industrial, biological, or materials-science outcome.

References: PubChem: Salicylhydroxamic Acid, CAS 89-73-6; biochemical literature on SHAM

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